Enzymes useful for the characterization and analysis of antibody-drug conjugates (ADCs).
Useful for the evaluation and analysis of important quality characteristics such as drug-antibody ratio (DAR), site occupancy, and in vivo changes of antibody-drug conjugates (ADCs).
<Introduction> Antibodies are challenging molecules to characterize due to their size and complexity. A compelling approach to combat diseases such as cancer is to conjugate drugs (payloads) to antibodies, but this further increases the risks of complexity and heterogeneity. Antibody-drug conjugates (ADCs), like other IgG-based biopharmaceuticals, require careful and detailed characterization and appropriate analytical workflows. The "FabRICATOR" product from Genovis allows for the digestion of ADCs into subunits, enabling detailed characterization of this complex class of drugs. Additionally, the endoglycosidases "IgGZERO" and "GlycINATOR" help reduce complexity and improve resolution, making intact ADC studies possible. [Genovis actively hosts web meetings and seminars. Please feel free to contact us for adjustments according to your needs.]
- Company：重松貿易 大阪本社
- Price：Other
